Operating Procedure for Purified Water Generation System

• Scope:This Standard Operating Procedure is applicable to the formulation plant of Pharmaceutical Company(Make-Neela Metal ,Capacity -2.5m³/hr) .
• Objective:To lay down an Operating Procedure for Purified Water Generation System.
• Volts: Voltage
• Amps : Amperes
• PH : Proportionate Hydrogen
• Kg/cm² :Kilogram per Centimeter Square
• m³/hr :Meter Cube per Hour
• µS/Cm: Micro Siemens per Centimeter
• UF: Ultra Filtrations
• EDI :Electro Deionization
• MCF: Micron Cartridge Filter
• NMT: Not More Than
• NLT: Not Less Than
• HPP: High Pressure Pump
• RO: Reverse Osmosis
• Abbreviations and Definitions:
• Accountability:Head-Engineering and QA shall be accountable for the compliance of the procedure as per this SOP.
• Responsibility
  • The Concerned Technician shall follow the Operating Procedure as per this SOP.
  • The Officer/Executive-Engineering shall be responsible for implementation of the procedure as per this SOP.
• Procedure
  • Switch “ON” the main switch of RO- panel.
  • Open the soft water supply pump suction valve and discharge valve
  • Start the soft water pump.
  • Start the dosing of anti-scalent and PH- correction.
  • Check the free chlorine and pH on ORP meter and PH check point.
  • Remove the air from MCF through vent valve.
  • Start the HPP and flush the RO-1 membranes for 5 to 10 minutes.
  • Adjust Valve to desired pressure and flow.
  • Membrane inlet water pressure – NMT 6.8 kg/ cm^2.
  • Permeate water flow -NLT 3.66 m³/hr.
  • Reject water pressure between 4 to 5 Kg/cm².
  • Reject water recirculation -NLT 2.5 m³/ hr.
  • Start the HPP  and flush the RO -2  for 5 to 10 minutes.
  • Adjust the V to design pressure and flow. (RO-]2)
  • Membrane inlet water pressure between 6 to 7 kg / cm²
  • Permeate water flow – NLT 3 m³ / hr.
  • Reject water pressure between 3 to 4 kg / cm².
  • Reject water recirculation flow 1.5 to 2 m³/ hr.
  • Start EDI feed pumps.
  • When water comes out from EDI start the rectifier..
  • Ensure the valve  is completely open.
  • EDI inlet water pressure – NMT 3.0 Kg/cm^2.
  • Permeate water flow – 2.6 m³/ hr.
  • Start the rectifier and adjust the current (6Amps-10Amps) and voltage (200Volts-300Volts) for required quality of water.
  • Adjust the Valve for the desired water flow from UF.
  • Permeate water flow – 2.5 m³/ hr.
  • Reject water pressure between 0.2 to 0.4 Kg / cm².
  • Record all the observation of Purified Water System in the Log Sheet. As per Operation.
  • Parameter Conductivity should be less than 60 µS /Cm for RO-1, less than 40 µS /Cm for RO-2 and less than 1.3 µS /Cm for after EDI and UF outlet.
• Forms and Annexure
• Logbook of Purified Water System : Annexure-I
• Distribution:
• Master Copy: Documentation Cell
• Controlled Copies: Engineering, Production, Quality Assurance,Warehouse, Quality Control, Administration and House Keeping
• History:                        

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