Production Quiz 01

Production Quiz 01

Question: What are the challenges faced in tablet manufacturing?

Answer: The challenges in tablet manufacturing include visual and functional defects, which have increased due to complexities in tablet presses and higher quality demands.

Question: Why have advancements and innovations in tablet manufacture not decreased the production problems?

Answer: The production problems have increased due to the complexities of tablet presses and the greater demands for quality.

Question: What are the major reasons for visual defects in tablets?

Answer: Visual defects are primarily caused by inadequate fines or moisture in granules ready for compression and faulty machine settings.

Question: What are the causes of functional defects in tablets?

Answer: Functional defects are attributed to faulty formulations in tablet manufacturing.

Question: How can manufacturing problems in tablet production be resolved?

Answer: Resolving manufacturing problems requires in-depth knowledge of granulation processing and tablet presses, acquired through exhaustive study and rich experience.

Question: What are the possible sources of tablet processing problems?

Answer: Tablet processing problems can arise from issues in the formulation, compression equipment, or a combination of both.

Question: What is capping in the context of tableting process defects?

Answer: Capping refers to the partial or complete separation of the top or bottom of a tablet, resulting from air entrapment in the granular material.

Question: What is lamination in tableting process defects?

Answer: Lamination is the separation of a tablet into two or more layers, caused by air entrapment in the granular material.

Question: What is the cause of cracking in tablets during the tableting process?

Answer: Cracking is caused by the rapid expansion of tablets when deep concave punches are used during the tableting process.

Question: How can capping be described in terms of tablet appearance?

Answer: Capping manifests as the partial or complete separation of the top or bottom of a tablet, affecting its overall appearance.

Question: What is the lamination in tablet manufacturing?

Answer: Lamination results in the tablet being divided into two or more layers, impacting its structural integrity and overall quality.

Question: What conditions or equipment usage lead to cracking in tablets?

Answer: Cracking occurs during the tableting process when deep concave punches are used, causing rapid expansion of the tablets.

Question: How is capping different from lamination in tablet defects?

Answer: Capping involves the separation of the top or bottom of a tablet, while lamination is the splitting of a tablet into two or more layers, both caused by air entrapment in the granular material.

Question: What are the visual indicators of cracking in tablets?

Answer: Cracking is visually indicated by the presence of fractures or breaks in tablets, especially when deep concave punches are employed.

Question: What is the cause of chipping in tablets?

Answer: Chipping in tablets is attributed to very dry granules.

Question: How is sticking defined in the context of tablet defects related to excipients?

Answer: Sticking is the adhesion of granulation material to the die wall during the tableting process.

Question: What is picking, and how does it occur in tablet manufacturing?

Answer: Picking is the removal of material from the surface of a tablet, followed by its adherence to the face of the punch during the tableting process.

Question: What is the common cause of problems like sticking, picking, and binding in tablets?

Answer: Problems such as sticking, picking, and binding are attributed to an excess amount of binder in the granules or the presence of wet granules.

Question: How is binding related to the amount of binder in the granules?

Answer: Binding issues arise due to an excessive amount of binder in the granules or the presence of wet granules during tablet manufacturing.

Question: What are the consequences of very dry granules in terms of tablet appearance and quality?

Answer: Very dry granules can lead to chipping in tablets, affecting their appearance and overall quality.

Question: What visual indicators suggest the occurrence of sticking in tablet production?

Answer: Sticking is visually indicated by the adhesion of granulation material to the die wall during the tableting process.

Question: How is picking different from binding in the context of tablet defects?

Answer: Picking involves the removal of material from the tablet surface, adhering to the face of the punch, while binding is a broader issue related to excess binder or wet granules.

Production Quiz 03