Production Quiz 01
Question: What are the challenges faced in tablet manufacturing?
Answer: The challenges in tablet manufacturing include visual and functional defects, which have increased due to complexities in tablet presses and higher quality demands.
Question: Why have advancements and innovations in tablet manufacture not decreased the production problems?
Answer: The production problems have increased due to the complexities of tablet presses and the greater demands for quality.
Question: What are the major reasons for visual defects in tablets?
Answer: Visual defects are primarily caused by inadequate fines or moisture in granules ready for compression and faulty machine settings.
Question: What are the causes of functional defects in tablets?
Answer: Functional defects are attributed to faulty formulations in tablet manufacturing.
Question: How can manufacturing problems in tablet production be resolved?
Answer: Resolving manufacturing problems requires in-depth knowledge of granulation processing and tablet presses, acquired through exhaustive study and rich experience.
Question: What are the possible sources of tablet processing problems?
Answer: Tablet processing problems can arise from issues in the formulation, compression equipment, or a combination of both.
Question: What is capping in the context of tableting process defects?
Answer: Capping refers to the partial or complete separation of the top or bottom of a tablet, resulting from air entrapment in the granular material.
Question: What is lamination in tableting process defects?
Answer: Lamination is the separation of a tablet into two or more layers, caused by air entrapment in the granular material.
Question: What is the cause of cracking in tablets during the tableting process?
Answer: Cracking is caused by the rapid expansion of tablets when deep concave punches are used during the tableting process.
Question: How can capping be described in terms of tablet appearance?
Answer: Capping manifests as the partial or complete separation of the top or bottom of a tablet, affecting its overall appearance.
Question: What is the lamination in tablet manufacturing?
Answer: Lamination results in the tablet being divided into two or more layers, impacting its structural integrity and overall quality.
Question: What conditions or equipment usage lead to cracking in tablets?
Answer: Cracking occurs during the tableting process when deep concave punches are used, causing rapid expansion of the tablets.
Question: How is capping different from lamination in tablet defects?
Answer: Capping involves the separation of the top or bottom of a tablet, while lamination is the splitting of a tablet into two or more layers, both caused by air entrapment in the granular material.
Question: What are the visual indicators of cracking in tablets?
Answer: Cracking is visually indicated by the presence of fractures or breaks in tablets, especially when deep concave punches are employed.
Question: What is the cause of chipping in tablets?
Answer: Chipping in tablets is attributed to very dry granules.
Question: How is sticking defined in the context of tablet defects related to excipients?
Answer: Sticking is the adhesion of granulation material to the die wall during the tableting process.
Question: What is picking, and how does it occur in tablet manufacturing?
Answer: Picking is the removal of material from the surface of a tablet, followed by its adherence to the face of the punch during the tableting process.
Question: What is the common cause of problems like sticking, picking, and binding in tablets?
Answer: Problems such as sticking, picking, and binding are attributed to an excess amount of binder in the granules or the presence of wet granules.
Question: How is binding related to the amount of binder in the granules?
Answer: Binding issues arise due to an excessive amount of binder in the granules or the presence of wet granules during tablet manufacturing.
Question: What are the consequences of very dry granules in terms of tablet appearance and quality?
Answer: Very dry granules can lead to chipping in tablets, affecting their appearance and overall quality.
Question: What visual indicators suggest the occurrence of sticking in tablet production?
Answer: Sticking is visually indicated by the adhesion of granulation material to the die wall during the tableting process.
Question: How is picking different from binding in the context of tablet defects?
Answer: Picking involves the removal of material from the tablet surface, adhering to the face of the punch, while binding is a broader issue related to excess binder or wet granules.
