Clean Room Quiz 4

Production Quiz 01

Production Quiz 01

Question: What are the challenges faced in tablet manufacturing?

Answer: The challenges in tablet manufacturing include visual and functional defects, which have increased due to complexities in tablet presses and higher quality demands.

Question: Why have advancements and innovations in tablet manufacture not decreased the production problems?

Answer: The production problems have increased due to the complexities of tablet presses and the greater demands for quality.

Question: What are the major reasons for visual defects in tablets?

Answer: Visual defects are primarily caused by inadequate fines or moisture in granules ready for compression and faulty machine settings.

Question: What are the causes of functional defects in tablets?

Answer: Functional defects are attributed to faulty formulations in tablet manufacturing.

Question: How can manufacturing problems in tablet production be resolved?

Answer: Resolving manufacturing problems requires in-depth knowledge of granulation processing and tablet presses, acquired through exhaustive study and rich experience.

Question: What are the possible sources of tablet processing problems?

Answer: Tablet processing problems can arise from issues in the formulation, compression equipment, or a combination of both.

Question: What is capping in the context of tableting process defects?

Answer: Capping refers to the partial or complete separation of the top or bottom of a tablet, resulting from air entrapment in the granular material.

Question: What is lamination in tableting process defects?

Answer: Lamination is the separation of a tablet into two or more layers, caused by air entrapment in the granular material.

Question: What is the cause of cracking in tablets during the tableting process?

Answer: Cracking is caused by the rapid expansion of tablets when deep concave punches are used during the tableting process.

Question: How can capping be described in terms of tablet appearance?

Answer: Capping manifests as the partial or complete separation of the top or bottom of a tablet, affecting its overall appearance.

Question: What is the lamination in tablet manufacturing?

Answer: Lamination results in the tablet being divided into two or more layers, impacting its structural integrity and overall quality.

Question: What conditions or equipment usage lead to cracking in tablets?

Answer: Cracking occurs during the tableting process when deep concave punches are used, causing rapid expansion of the tablets.

Question: How is capping different from lamination in tablet defects?

Answer: Capping involves the separation of the top or bottom of a tablet, while lamination is the splitting of a tablet into two or more layers, both caused by air entrapment in the granular material.

Question: What are the visual indicators of cracking in tablets?

Answer: Cracking is visually indicated by the presence of fractures or breaks in tablets, especially when deep concave punches are employed.

Question: What is the cause of chipping in tablets?

Answer: Chipping in tablets is attributed to very dry granules.

Question: How is sticking defined in the context of tablet defects related to excipients?

Answer: Sticking is the adhesion of granulation material to the die wall during the tableting process.

Question: What is picking, and how does it occur in tablet manufacturing?

Answer: Picking is the removal of material from the surface of a tablet, followed by its adherence to the face of the punch during the tableting process.

Question: What is the common cause of problems like sticking, picking, and binding in tablets?

Answer: Problems such as sticking, picking, and binding are attributed to an excess amount of binder in the granules or the presence of wet granules.

Question: How is binding related to the amount of binder in the granules?

Answer: Binding issues arise due to an excessive amount of binder in the granules or the presence of wet granules during tablet manufacturing.

Question: What are the consequences of very dry granules in terms of tablet appearance and quality?

Answer: Very dry granules can lead to chipping in tablets, affecting their appearance and overall quality.

Question: What visual indicators suggest the occurrence of sticking in tablet production?

Answer: Sticking is visually indicated by the adhesion of granulation material to the die wall during the tableting process.

Question: How is picking different from binding in the context of tablet defects?

Answer: Picking involves the removal of material from the tablet surface, adhering to the face of the punch, while binding is a broader issue related to excess binder or wet granules.

Production Quiz 03

About Pharmaguidanaces Channel

Ms. Abha Maurya is the Author and founder of pharmaceutical guidance, he is a pharmaceutical Professional from India having more than 18 years of rich experience in pharmaceutical field. During his career, he work in quality assurance department with multinational company’s i.e Zydus Cadila Ltd, Unichem Laboratories Ltd, Indoco remedies Ltd, Panacea Biotec Ltd, Nectar life Science Ltd. During his experience, he face may regulatory Audit i.e. USFDA, MHRA, ANVISA, MCC, TGA, EU –GMP, WHO –Geneva, ISO 9001-2008 and many ROW Regularities Audit i.e.Uganda,Kenya, Tanzania, Zimbabwe. He is currently leading a regulatory pharmaceutical company as a head Quality. You can join him by Email, Facebook, Google+, Twitter and YouTube

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