Question: What is mottling, and what factors contribute to this defect in tablets?
Answer: Mottling is a tablet defect that can be caused by colored drugs (Excipient-related), improper mixing of granular material (Process-related), dirt in the granular material, or the use of oily lubricant, leading to oil spots.
Answer: How does the color of a drug contribute to mottling?
A2: Mottling can occur if a drug with a color different from the rest of the granular material is used, contributing to the defect.
Question: What role does improper mixing play in the occurrence of mottling in tablets?
Answer: Improper mixing of granular material during the tableting process can contribute to the occurrence of mottling.
Question: How can dirt in the granular material or on punch faces lead to mottling in tablets?
Answer: The presence of dirt in the granular material or on punch faces during tablet manufacturing can contribute to the defect of mottling.
Question: What is the cause of double impressions in tablet production?
Answer: Double impression occurs due to the free rotation of punches with engraving on their faces during tablet manufacturing.
Question: How is mottling related to formulation and machine factors?
Answer: Mottling can be related to formulation issues (granulation) such as colored drugs and machine-related factors like improper mixing, dirt, and the use of oily lubricant.
Question: What are the potential remedies for mottling in tablets?
Answer: Remedies for mottling may include addressing the factors contributing to the defect, such as using proper mixing techniques, avoiding colored drugs causing mottling, and ensuring cleanliness.
Question: How does the free rotation of punches contribute to double impression in tablet production?
Answer: Double impression occurs when punches with engraving on their faces experience free rotation during tablet manufacturing.