SOP on Handling of Hazardous Chemicals

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SOP on Handling of Hazardous Chemicals

1.0 OBJECTIVE

To lay down a systematic procedure for the safe handling, storage, and usage of hazardous chemicals to ensure personnel safety and compliance with regulatory requirements.

2.0 SCOPE

This SOP is applicable to all personnel involved in handling hazardous chemicals.

3.0 RESPONSIBILITY

3.1 Officer and above shall be responsible for preparation of the SOP.
3.2 Executive and above shall be responsible for review and verification of the SOP.
3.3 Head – Quality Assurance shall be responsible for approval of the SOP.

4.0 ACCOUNTABILITY

The Head – Quality Control shall be accountable for implementation and compliance with this SOP.

5.0 DEFINITIONS & ABBREVIATIONS

5.1 Definitions

  • Hazardous chemicals shall be handled only in approved containers.
  • Hands shall be thoroughly washed after handling any hazardous material.
  • Chemicals shall be stored as per label instructions and compatibility requirements.
  • Flammable chemicals shall be stored in cool, dry areas away from heat and direct sunlight.
  • Incompatible chemicals (e.g., acids) shall be stored separately to prevent reactions.

5.2 Abbreviations

  • SOP – Standard Operating Procedure
  • QA – Quality Assurance
  • QC – Quality Control
  • CCF – Change Control Format
  • IPA – Isopropyl Alcohol
  • SS – Stainless Steel

6.0 PRECAUTIONS, SAFETY & EHS

6.1 Ensure that chromic acid solution is within its validity period before use.
6.2 Handle and clean glassware carefully to avoid exposure and breakage.
6.3 Always use appropriate Personal Protective Equipment (PPE) while handling hazardous chemicals.
6.4 Follow all applicable Environmental Health and Safety (EHS) guidelines.

7.0 MATERIALS & EQUIPMENT REQUIRED

7.1 Materials

  • Glassware to be cleaned
  • Raw water
  • Demineralized (DM) water
  • Detergent
  • Chromic acid solution
  • Bottle brush

7.2 Equipment

  • Drying oven

8.0 PROCEDURE

8.1 General Handling

8.1.1 Hazardous chemicals shall be handled only under the supervision of an authorized person.
8.1.2 Appropriate PPE such as acid-resistant gloves, safety goggles, respirators, and protective clothing shall be used.
8.1.3 Transfer and preparation of hazardous chemicals shall be carried out in a fume hood.
8.1.4 Avoid direct exposure; maintain a safe distance while pouring or transferring chemicals.
8.1.5 Use suction bulbs or vacuum devices for pipetting; mouth pipetting is strictly prohibited.

8.2 Preparation of Solutions

8.2.1 Exercise special precautions while preparing dilute solutions of sulphuric acid, perchloric acid, and chromic acid.
8.2.2 For dilution of sulphuric acid:

  • Cool water in an ice bath before use.
  • Slowly add acid to water with continuous stirring.
  • Never add water to acid, as it may cause splashing or violent reactions.

8.3 Storage and Handling

8.3.1 Store flammable chemicals away from open flames, sparks, and heat sources.
8.3.2 Store all chemicals in designated storage cabinets as per compatibility.
8.3.3 Poisonous chemicals shall be stored under lock and key with appropriate hazard labeling.
8.3.4 Maintain proper labeling on all containers, including hazard warnings and safety instructions.
8.3.5 Follow all safety signs and instructions indicated on reagent bottles.

8.4 Spill Management

8.4.1 Any chemical spillage shall be cleaned immediately using appropriate procedures and materials.
8.4.2 Report all spillages and incidents to the supervisor without delay.

8.5 Control of Poisonous Chemicals

8.5.1 For highly toxic chemicals such as Potassium Cyanide, Arsenic Trioxide, and Lead Acetate:

  • Maintain a logbook for stock and usage.
  • Ensure restricted access and controlled handling.

9.0 RECORDS

  • Stock and usage records of hazardous/poisonous chemicals
  • Cleaning and maintenance records (if applicable)

10.0 REFERENCES

  • EHS Guidelines
  • Laboratory Safety Manuals
  • Applicable regulatory guidelines (GMP/WHO)
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