Amgen Manager QC – North Carolina: Quality Control Job Opening in Holly Springs

Amgen Manager QC Job in North Carolina – Night Shift

Amgen has announced an exciting opportunity for experienced Quality Control professionals at its biotechnology facility in Holly Springs, North Carolina, USA. The position, Manager Quality Control I – Nights, offers an opportunity to lead night-shift QC operations, support manufacturing activities, and maintain compliance with Good Manufacturing Practices (GMP), data integrity, and laboratory quality standards.

The Amgen Manager QC position is designed for professionals with strong technical expertise, analytical testing experience, and leadership capabilities in a regulated laboratory environment. Candidates with experience in chemistry, bioassay, microbiology, laboratory information management systems, and pharmaceutical quality control may find this opportunity particularly relevant.

Interested candidates should review the qualifications, responsibilities, salary information, and application instructions below before applying through Amgen’s official careers website.

Amgen Manager QC Job Details

Job Information	Details
Company	Amgen
Job Title	Manager Quality Control I – Nights
Job ID	R-257054
Focus Keyword	Amgen Manager QC
Location	Holly Springs, North Carolina, USA
Work Location Type	On-site
Job Category	Quality
Work Schedule	Wednesday–Saturday, night shift
Annual Salary Range	$114,063.20–$154,320.80 USD
Date Posted	October 1, 2026
Application Deadline	No fixed deadline
Official Careers Website	careers.amgen.com

About Amgen

Amgen is a biotechnology company established in 1980, focused on developing innovative medicines for patients living with serious illnesses. Its therapeutic areas include oncology, inflammation, general medicine, and rare diseases.

The company emphasizes scientific innovation, collaboration, and patient-focused healthcare. Joining Amgen provides professionals with an opportunity to contribute to the quality and reliability of medicines through their work in regulated manufacturing and laboratory environments.

Job Responsibilities: Amgen Manager QC

The successful candidate will report directly to the Director of Quality Control and provide independent technical execution and shift-level leadership within a GMP-regulated laboratory.

Key responsibilities include:

1. Night-Shift Quality Control Operations

• Lead and coordinate night-shift QC laboratory activities.
• Manage sample receipt, prioritization, and accurate entry into the Laboratory Information Management System (LIMS).
• Support timely analytical testing to meet manufacturing requirements.
• Ensure appropriate communication of laboratory issues and operational risks.

2. Analytical Testing and Laboratory Support

• Independently perform routine and complex analytical testing.
• Support testing activities in chemistry, bioassay, and/or microbiology.
• Perform STAT testing when required to support manufacturing schedules.
• Identify testing-related issues and communicate significant concerns to QC leadership.

3. GMP Compliance and Data Integrity

The Amgen Manager QC role requires a strong understanding of laboratory compliance and documentation requirements.

Responsibilities include:

• Maintain compliance with current Good Manufacturing Practices (GMP).
• Follow Good Documentation Practices (GDP).
• Ensure accurate, complete, and traceable laboratory records.
• Apply relevant electronic-record requirements, including 21 CFR Part 11.
• Support investigations associated with deviations and out-of-specification (OOS) results.
• Maintain laboratory safety and established quality standards.

4. Electronic Laboratory Systems

Candidates should be familiar with electronic systems used to manage laboratory testing, documentation, and quality processes.

The systems identified in the job description include:

• Laboratory Information Management System (LIMS)
• BIOVIA Laboratory Execution System (LES)
• Electronic Laboratory Notebook (ELN)
• CIMS/CISPro
• Veeva Vault QualityDocs
• Veeva Vault Quality Management System (QMS)

Experience with these platforms can help candidates support accurate sample tracking, reliable laboratory records, and efficient quality control workflows.

5. Manufacturing Coordination and Continuous Improvement

• Serve as the primary QC point of contact for Manufacturing during night-shift operations.
• Coordinate testing priorities with production schedules.
• Support issue resolution and timely escalation of quality risks.
• Collaborate with cross-functional teams.
• Contribute to continuous improvement initiatives and laboratory efficiency.

Educational Qualifications and Experience

To qualify for the Amgen Manager QC position, candidates must meet at least one of the following education and experience combinations:

• High school diploma or GED: 12 years of Quality Control experience.
• Associate’s degree: 10 years of Quality Control experience.
• Bachelor’s degree: 5 years of Quality Control experience.
• Master’s degree: 3 years of Quality Control experience.
• Doctorate degree: As specified in the official posting.

In addition to meeting one of these pathways, candidates must have experience directly managing people and/or relevant leadership experience involving teams, projects, programs, or resource allocation. Management experience may overlap with the required technical experience.

Applicants should check the official posting for the complete eligibility criteria.

Preferred Qualifications

Amgen identifies the following qualifications and skills as desirable:

• Bachelor’s degree in a scientific discipline or equivalent experience.
• Experience in a GMP-regulated Quality Control laboratory.
• Ability to work independently and make appropriate decisions.
• Previous experience as a shift lead, laboratory point of contact, or informal team leader.
• Hands-on analytical testing experience in chemistry, bioassay, and/or microbiology.
• Strong knowledge of GMP, GDP, data integrity, and 21 CFR Part 11.
• Familiarity with compendial methods, including USP–NF.
• Excellent communication and organizational skills.
• Strong problem-solving abilities and attention to detail.
• Ability to manage multiple priorities in a fast-paced manufacturing environment.

Salary and Employee Benefits

The advertised annual salary range for the Amgen Manager QC position is $114,063.20 to $154,320.80 USD, excluding Puerto Rico. Actual compensation may vary depending on relevant skills, qualifications, experience, and other factors.

Amgen offers an employee Total Rewards Plan, subject to eligibility and applicable plan terms. Benefits described in the job posting may include:

• Retirement and Savings Plan with company contributions.
• Medical, dental, and vision insurance.
• Life and disability insurance.
• Flexible spending accounts.
• Discretionary annual bonus opportunities.
• Stock-based long-term incentives.
• Paid time-off programs.
• Career development opportunities.
• A collaborative and science-based working environment.

Work Schedule and Location

This is an on-site night-shift position at Amgen’s Holly Springs facility in North Carolina. The specified schedule is Wednesday through Saturday.

Candidates should consider the night-shift requirements and on-site work arrangement before applying. Applicants who require employment sponsorship should also note that sponsorship is not guaranteed for this role.

How to Apply for Amgen Manager QC

Interested candidates can submit their applications through the official Amgen recruitment portal.

Application steps:

1. Open the official application link below.
2. Search for or confirm the position title: Manager Quality Control I – Nights.
3. Verify job ID R-257054.
4. Review the complete job requirements and application instructions.
5. Prepare an updated resume highlighting QC experience, GMP compliance, analytical testing, data integrity, electronic laboratory systems, and leadership responsibilities.
6. Complete and submit the online application.

Apply online: Amgen Manager Quality Control I – Nights – Official Application

APPLY NOW

Amgen has stated that this position does not have a fixed application deadline. Applications will continue to be accepted until a sufficient number of candidates have been received or a candidate is selected. The vacancy may close at any time.

Frequently Asked Questions

1. What is the job title?

The official title is Manager Quality Control I – Nights.

2. Where is the job located?

The position is based on-site in Holly Springs, North Carolina, USA.

3. What is the salary range?

The advertised annual salary range is $114,063.20–$154,320.80 USD.

4. What is the work schedule?

The position follows a Wednesday-to-Saturday night-shift schedule.

5. Is GMP experience important?

Yes. Experience in a GMP-regulated QC laboratory and knowledge of GDP, data integrity, and electronic-record requirements are among the preferred qualifications.

6. Is visa sponsorship guaranteed?

No. Amgen states that sponsorship for this role is not guaranteed.

Conclusion

The Amgen Manager QC opportunity in Holly Springs, North Carolina, is relevant to experienced Quality Control professionals seeking a laboratory leadership role in the biotechnology industry. The position combines analytical testing, night-shift operations, manufacturing support, electronic laboratory systems, and GMP compliance.

Candidates who meet the educational and experience requirements should review the official vacancy and submit their applications through Amgen’s recruitment portal. Always verify the current job status and eligibility requirements before applying.