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Powder flow properties in Pharmaceuticals

Powder flow properties in Pharmaceuticals

Apparent bulk density (g/cm3):

Bulk drug powder is sieved through 40 mesh screen.
Weight is taken and poured into a graduated cylinder via a large funnel. The volume is called bulk volume.
Apparent bulk density = Weight of the powder/Bulk volume

Tapped density (g/cm3):

Bulk powder is sieved through 40 mesh screen. Weight is
taken and poured into a graduated cylinder. The cylinder is tapped 1000 times on a mechanical tapper apparatus. The volume reaches a minimum – called tapped volume.
Tapped density =  Weight of the powder/ Tapped volume

True density (g/cm3):

Solvents of varying densities are selected in which the powder sample is insoluble. Small quantity of surfactant may be mixed with the solvent mixture to enhance wetting and pore penetration. After vigorous agitation, the samples are centrifuged briefly and then left to stand undisturbed until floatation or settling has reached equilibrium.

The samples that remains suspended (i.e. neither suspended not floated) is taken. So the true density of the powder is equal. So the true density of the powder is the density of that solvent. The density of that solvent is determined accurately with a pycnometer.

Source of Variation of Bulk Density:

Method of crystallization, milling, formulation

Methods of correction:

By milling, slugging or formulation


Bulk density:

Bulk density is required during the selection of capsule size for a high dose drug.
• In case of low dose drug mixing with excipients is a problem if the bulk densities of the drug and excipients have large difference.

• Near the bottom, a set of scanning coils moves the focused beam back and forth across the specimen, row by row.

• As the electron beam hits each spot on the sample, secondary electrons are knocked loose from its surface. A detector counts these electrons and sends the signals to an amplifier.

• The final image is built up from the number of electrons emitted from each spot on the sample.

Powder flow properties:
Powder flow properties depend on
(i) particle size
(ii) density
(iii) shape
(iv) electrostatic charge and adsorbed moisture

that may arise from processing or formulation.

A free-flowing powder may become cohesive during development. This problem may be solved by any of the following ways:
(i) by granulation
(ii) by densification via slugging
(iii) by filling special auger feed equipment (in case of powder)
(iv) by changing the formulation.

For free flowing powder: A simple flow rate apparatus consists of a grounded metal tube from which drug flows through an orifice onto an electronic balance, which is connected to a strip chart recorder. Several flow rate (g/sec) determinations at various orifice sizes (1/8 to ½ inch) should be carried out.

The greater the standard deviation between multiple flow rate measurements, the greater will be the weight variation of the product (tablets or capsules).






About Pharmaceutical Guidanace

Mr. Shiv Kumar is the Author and founder of pharmaceutical guidance, he is a pharmaceutical Professional from India having more than 14 years of rich experience in pharmaceutical field. During his career, he work in quality assurance department with multinational company’s i.e Zydus Cadila Ltd, Unichem Laboratories Ltd, Indoco remedies Ltd, Panacea Biotec Ltd, Nectar life Science Ltd. During his experience, he face may regulatory Audit i.e. USFDA, MHRA, ANVISA, MCC, TGA, EU –GMP, WHO –Geneva, ISO 9001-2008 and many ROW Regularities Audit i.e.Uganda,Kenya, Tanzania, Zimbabwe. He is currently leading a regulatory pharmaceutical company as a head Quality. You can join him by Email, Facebook, Google+, Twitter and YouTube

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