SOP for for Calibration of Gas Chromatography (GC)

  • Objective: To lay down a procedure for Calibration of Gas Chromatography (GC).
  • Scope: This Standard Operating Procedure is applicable for for Calibration of Gas Chromatography (GC).
  • 3.0 RESPONSIBILITY:
    • All concerned personnel shall responsible to follow the procedure mention in this SOP.
    • Concerned Department Heads shall be responsible for compliance of the procedure.

    4.0 ACCOUNTABILITY:

    Production and QA Head shall be accountable that this SOP is implemented as per laid down procedure.

    5.0 ATTACHMENTS:

    CALIBRATION OF AUTO INJECTOR BY LINEARITY (CAPILLARY COLUMN) – Attachment – I

    CALIBRATION OF AUTO INJECTOR BY LINEARITY (CAPILLARY COLUMN)– Attachment – II

    CALIBRATION  FOR COLUMN OVEN TEMPERATURE– Attachment – III

    GC CALIBRATION TEMPLATE FOR VIAL TEMPERATURE –  Attachment – IV

     

    6.0 PROCEDURE:

  • During calibration enter the details in the respective attachments of this SOP and compare the obtained results to the specified limits given in the respective template.
  • If  any noncompliance observed, inform  to Head QC and follow the SOP on “ Handling of out of calibration.
  • After completion of calibration submit the report for checking.
  • affix the calibration status label on the instrument  and records the details of calibration in respective logs after completion of calibration.
  •  Check and verified the leakage at the Joints with 50% v/v  soap solution in water prior to use (Near septum nut, around injection port nut, at column connection).
  • Calibration of Headspace incubator temperature and column oven temperature shall be preform by external party.
  • For Calibration procedure and acceptance criteria refer respected calibration attachments.
  • Calibration Frequency: monthly. (± 2 days)
  • 7.0 REFERENCES:
  • ISO 2859-1:19998.0 ABBREVIATIONS:SOP: Standard Operation Procedure9.0 DISTRIBBUTION LIST:Quality AssuranceHuman Resource and administrationProductionQuality Control

    Warehouse

    Engineering

    Purchase

    10.0 HISTORY OF REVISION:

    Version No. Effective Date Reason for revision
         

     

    A 9 -

    A 7 -

    A 8 -

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